Injectable Hydrogels in Repairing Central Nervous System Injuries

The injured central nervous system (CNS) can hardly regenerate. In vitro engineering of brain tissue hits technical bottlenecks. Also, the compaction and complexity anatomical structure defy accurate positioning for lesion sites in intracranial injuries. Therefore, repairing CNS remains a significant clinical challenge. Various recent vivo experiments have demonstrated excellent effect on nerve cells tissues through implanting new materials engineered cells. Except porous three-dimensional structures able to pad lesions various shapes simulate natural extracellular matrix with nutrients cell proliferation, hydrogels incorporate high biocompatibility. Injectable merits avoiding complex surgery large wounds, filling irregular gaps, delivering drugs, others, are growing interest. This review focuses experimental studies regarding injectable hydrogels, especially applying repair damage.